Automated Tangential Flow Filtration System - PureTec® | Product Series

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Automated Tangential Flow Filtration System - PureTec®

Automated Tangential Flow Filtration System - PureTec®

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The SciLog PureTec® is a complete TFF development system with real time data collection, automated pressure control, and scalable parameters for easy technology transfer.

Technical Specifications

  • Brand: SciLog
  • Division: Bioscience and Water Filtration Division
  • Industry: Biopharmaceuticals, Pharmaceuticals
  • Application: Tangential Flow Filtration
  • Technology: Filtration, Process Control
  • Product Type: Automated Laboratory System
  • Product Series: PureTec
  • Flow Rate: up to 2000 ml/min
  • Operating Pressure: 25 psi (continuous), 45 psi (max.)
  • Height: 216 mm, 8.5 inch
  • Depth: 279 mm, 11 inch
  • Width: 146 mm, 5.75 inch
  • Weight: 14 lb, 6.4 kg
  • Accessories Included: 3 SciPres Sensors, 8.1 kg Balance, 500 ml Vessel With Magnetic Stirrer, Start-Up Kit Including Tubing and Fittings

Full Product Description

The SciLog® PureTec® is a laboratory-scale tangential flow filtration (TFF) and parameter development system.

The PureTec® system is delivered as a complete development system including three pressure sensors, an 8.1 kg balance, a 500 ml vessel with magnetic stirrer and a start-up kit including tubing and fittings.

The automatic documentation and alarm / pump stop settings allow the user to focus on other tasks while the system is running. Programmable end points ensure the system spops operating when a user defined concentration or diafiltration is reached.

When used with SciDoc software or a printer, documentation capabilities include 17 real-time filtration parameters such as TMP, permeate flow rate and quantity, normalized water permeability (NWP), concentration factor, and other parameters over time.

Features and Benefits

• Complete development system
• Real-time data collection with optimization tools
• Scalable parameters for easy technology transfer
• Flow and automated pressure control
• Safe, walk-away system operation
• Intuitive application interface

Concentration

In the constant pump rate or pressure modes, you can implement your scheduled pump rate or pressures and use some or all of five alarm conditions. The pump rate or pressures can be increased or decreased without stopping the pump action.

In the constant rate mode, increasing the reed rate in a stepwise fashion and simultaneously monitoring the permeate collection rate allows you to readily determine the optimal feed rate with the highest permeate yield.

In the constant pressure mode, increasing the trans-membrane pressure (TMP) in a step-wise fashion and simultaneously monitoring the permeate collection rate allows you to determine the optimal TMP with the highest permeate yield.

Diafiltration

In diafiltration procedures, a protein solutions is “washed”, i.e. de-salted, using an exchange of buffer to remove undesirable electrolyte (dissolved salt). The concentrated protein solution is re-circulated through a TFF filter whose selected porosity allows only the undesirable electrolyte to pass through the filter pores, which is collected as permeate. The permeate volume that has been removed from the concentrated protein solution (retentate) is replaced with an (desirable) exchange buffer.

In constant volume diafiltration or “washing”, the collected electrolyte is automatically replaced by an equal volume of exchange buffer. Approximately ten times volume exchanges are typically required for substantial removal of undesirable electrolyte from the concentrated protein solution.

Diafiltration via Suction:For small volumes, a SciLog® pressure vessel stored with buffer can be connected to the secondary inlet port on the retentate vessel. While keeping a closed system, the retentate vessel will automatically draw out buffer to replace the salt and solvent that has been removed by the filter. The process will continue until the PureTec® has reached its programmable end points.

Diafiltration via ChemTec®:For larger volumes, the SciLog® ChemTec® System and an appropriately sized balance will monitor and maintain the fluid in the PureTec®’s retentate vessel. The ChemTec® will maintain the level until a user defined volume exchange has been reached.

For more information on tangential flow filtration or other biopharmaceutical applications see the “Related Documents” section below.

Related Documents

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